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教授

扈洪波

發布日期:2012-05-16   瀏覽次數:
姓名 扈洪波
性別
出生日期
籍貫
民族
學歷/學位
職稱 教授

聯系方式

E-mail:hongbo@cau.edu.cn
通信地址:北京市清華東路17號中國農業大學食品科學與營業工程學院

學習工作經歷

現任職務(社會兼職等)

主要研究方向

1. 營養/食物因素對癌癥形成的調控作用及其分子機制
2. 程序性細胞死亡(apoptosis, autophagy, necroptosis, paraptosis)的調控機制研究
3. 食品中內分泌干擾物質檢測, 內分泌干擾毒性評價及毒理學機制

代表著作與論文

1) Hongbo Hu, Yubo Chai, Lei Wang, Jinhui Zhang, Hyo Jeong Lee, Sung-Hoon Kim, and Junxuan Lü Pentagalloylglucose induces autophagy and caspase-independent programmed deaths in human PC-3 and mouse TRAMP-C2 prostate cancer cells. Mol Cancer Ther October 2009 8:2833-2843

2) Hongbo Hu, Jinhui Zhang, Hyo Jeong Lee, Sung-Hoon Kim, Junxuan Lü Penta-O-galloyl-beta-D-glucose induces S- and G1-cell cycle arrests in prostate cancer cells targeting DNA replication and cyclin D1. Carcinogenesis 2009; 30(5):818-23

3) Hongbo Hu, Hyo-Jeong Lee, Cheng Jiang, Jinhui Zhang, Lei Wang, Yan Zhao, Qiu Xiang, Sung-Hoon Kim and Junxuan Lu. Penta-1,2,3,4,6-O-galloyl-beta-D- glucose induces p53 and inhibits STAT3 in prostate cancer cells in vitro and suppresses prostate xenograft tumor growth in vivo. Mol Cancer Ther. 2008 Sep;7(9):2681-91

4) Hongbo Hu, Guang-Xun Li, Lei Wang, Jenifer Watts, Gerald F Combs and Junxuan Lü. Methylseleninic acid enhances taxane drug efficacy against human prostate cancer and down regulates anti-apoptotic proteins Bcl-XL and survivin. Clinical Cancer Research. 2008;14,1150-1158

5) Hongbo Hu, Cheng Jiang, Todd Schuster, Guang-Xun Li, Peter T. Daniel and Junxuan Lü. Inorganic selenium sensitizes prostate cancer cells to TRAIL-induced apoptosis through superoxide/p53/Bax-mediated activation of mitochondrial pathway. Mol Cancer Ther. 2006;5:1873-82. (Selected for oral presentation at the 2006 AACR Annual Meeting in Washington, DC).

主要科研項目

教學工作

獎勵及其它




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